Medicinal, Psychological, and Health Research Journal (MPHRJ)

Comparison of Hemodynamic Responses to 50 Microgram Fentanyl Administration Across Different Age Groups During General Anesthesia

Document Type : Original Article

Authors

Yashar Eslampoor 1
Naghi Abedini 2

1 Assistant Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 Associate Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

https://doi.org/10.22034/mphrj.2026.586277.1098
Abstract
Introduction: Given the importance of maintaining cardiovascular stability during anesthesia and the potential influence of age on opioid responsiveness, further investigation into the hemodynamic effects of fentanyl across different age groups is warranted. The present study was designed to compare the hemodynamic responses associated with administration of 50 micrograms of fentanyl during general anesthesia among patients of different age categories.

Material and methods: This prospective study was conducted in 2025 at Shohada Hospital to evaluate age related hemodynamic responses to fentanyl during general anesthesia. A total of 100 patients were enrolled using convenience sampling and categorized into four age groups. All participants received 50 µg intravenous fentanyl during anesthetic induction. Hemodynamic parameters, including heart rate and blood pressure, were recorded every five minutes for one hour.

Results: Younger patients (18–30 years) exhibited higher baseline hemodynamic values and greater early fluctuations, whereas patients older than 50 years showed lower baseline values and more sustained declines. Significant time–age interactions were observed for heart rate (P = 0.021), systolic blood pressure (P = 0.014), and diastolic blood pressure (P = 0.018). Supplemental opioid requirements showed only modest intergroup variation.

Conclusion: Age significantly influences cardiovascular responses to fentanyl during general anesthesia. Older patients demonstrated greater hemodynamic vulnerability and less physiologic stability, while younger individuals exhibited more dynamic but transient cardiovascular changes. Despite these differences, supplemental opioid requirements remained relatively comparable among age groups, emphasizing the importance of individualized intraoperative monitoring and anesthetic management rather than opioid dosing based solely on chronological age.

Graphical Abstract

Comparison of Hemodynamic Responses to 50 Microgram Fentanyl Administration Across Different Age Groups During General Anesthesia

Keywords

Fentanyl
General anesthesia
Hemodynamic response
Heart rate
Opioid requirement
Subjects
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Medicinal, Psychological, and Health Research Journal (MPHRJ)
Volume 2, Issue 4
July and August 2026
Pages 295-305

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