Secondary Intention Healing Combined with Flap Reconstruction Versus Secondary Intention Healing Alone in Cutaneous Surgery: A Comparative Analysis of Wound Size Changes
Assistant Professor of Dermatology, Department of Dermatology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
10.22034/mphrj.2026.607873.1126
Abstract
Introduction: While secondary intention healing and local flap reconstruction are standard for cutaneous defects, their combined dimensional kinetics remain poorly understood. Balancing wound contraction with structural stability requires comparative evaluation. Therefore, this study aimed to evaluate and compare wound size changes between secondary intention healing combined with flap reconstruction versus secondary intention healing alone in cutaneous surgery.
Material and methods: This single-blind randomized trial at Sina Hospital enrolled 20 patients (10 per group via convenience sampling) to compare secondary intention healing combined with local flap reconstruction versus secondary intention healing alone for cutaneous surgical defects, evaluating wound dimensional changes over 12 weeks.
Results: Baseline defect area strongly predicted healing duration (r=0.872, R2 = 0.761, P=0.0010). Gender showed no significant differences in defect size (P=0.377) or healing time (P=0.066). Healing milestones occurred at 4 weeks (30%), 6 weeks (30%), and 8 weeks (40%).
Conclusion: Initial surgical defect size is a primary determinant of cutaneous recovery kinetics, whereas gender exerts no confounding effect, supporting the clinical utility of defect-guided reconstructive planning and secondary intention management.
Sheikhalizadeh Nobar, F. (2026). Secondary Intention Healing Combined with Flap Reconstruction Versus Secondary Intention Healing Alone in Cutaneous Surgery: A Comparative Analysis of Wound Size Changes. (e255148). Medicinal, Psychological, and Health Research Journal (MPHRJ), (), e255148 https://doi.org/10.22034/mphrj.2026.607873.1126
MLA
Sheikhalizadeh Nobar, F. "Secondary Intention Healing Combined with Flap Reconstruction Versus Secondary Intention Healing Alone in Cutaneous Surgery: A Comparative Analysis of Wound Size Changes" .e255148 , Medicinal, Psychological, and Health Research Journal (MPHRJ), , 2026, e255148. doi: 10.22034/mphrj.2026.607873.1126
HARVARD
Sheikhalizadeh Nobar F. (2026). 'Secondary Intention Healing Combined with Flap Reconstruction Versus Secondary Intention Healing Alone in Cutaneous Surgery: A Comparative Analysis of Wound Size Changes', Medicinal, Psychological, and Health Research Journal (MPHRJ), (), e255148. doi: 10.22034/mphrj.2026.607873.1126
CHICAGO
F. Sheikhalizadeh Nobar, "Secondary Intention Healing Combined with Flap Reconstruction Versus Secondary Intention Healing Alone in Cutaneous Surgery: A Comparative Analysis of Wound Size Changes," Medicinal, Psychological, and Health Research Journal (MPHRJ), (2026): e255148, doi: 10.22034/mphrj.2026.607873.1126
VANCOUVER
Sheikhalizadeh Nobar F. Secondary Intention Healing Combined with Flap Reconstruction Versus Secondary Intention Healing Alone in Cutaneous Surgery: A Comparative Analysis of Wound Size Changes. Medicinal, Psychological, and Health Research Journal (MPHRJ). 2026;():e255148. doi: 10.22034/mphrj.2026.607873.1126
