Artificial Intelligence in Early Detection of Skin Cancer

Document Type : Original Article

Author

Department of Chemical Engineering, Calgary University, Canada

10.22034/mphrj.2026.585087.1091
Abstract
Skin cancer is one of the most common malignancies worldwide, and its early detection remains essential for improving survival rates and reducing healthcare burdens. Dermoscopy has significantly enhanced the diagnostic accuracy of skin cancer by allowing detailed visualization of subsurface skin structures, but its interpretation depends heavily on clinical expertise and experience. In recent years, artificial intelligence (AI) has emerged as a transformative tool in medical imaging, particularly in dermatology, enabling automated, rapid, and highly accurate analysis of dermoscopic images. This study explores the integration of AI techniques—such as convolutional neural networks (CNNs), deep learning, and ensemble models—for the early detection and classification of skin lesions, including melanoma, basal cell carcinoma, and benign nevi. By leveraging large annotated datasets and advanced feature extraction algorithms, AI-based diagnostic systems can identify subtle visual patterns that may elude human observation. The paper reviews the main architectures applied to dermoscopy, discusses data preprocessing and augmentation strategies, and analyzes the performance of AI compared to dermatologists in clinical studies. Moreover, it highlights explainability, interpretability, and ethical considerations in AI-assisted diagnosis, ensuring transparency and trust in clinical applications. Results from recent research indicate that AI models achieve dermatologist-level accuracy and can serve as valuable decision-support systems, particularly in teledermatology and resource-limited settings. The findings suggest that AI-powered dermoscopic analysis represents a paradigm shift toward personalized, accessible, and efficient skin cancer screening, with significant implications for global public health and digital medicine.

Graphical Abstract

Artificial Intelligence in Early Detection of Skin Cancer

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[1]                Abbas, Q., Celebi, M. E., & Garcia, I. F. (2019). Skin tumor area extraction using an improved dynamic programming approach. Skin Research and Technology, 25(3), 418-428.
[2]                Abdolmaleki, Z., Mashak, Z., & Safarpoor Dehkordi, F. (2020). Molecular and virulence characteristics of methicillin-resistant Staphylococcus aureus bacteria recovered from hospital cockroaches. Jundishapur Journal of Microbiology, 12(12), e98564.
[3]                Alijani, H. Q., Fathi, A., Amin, H. I. M., Lima Nobre, M. A., Akbarizadeh, M. R., Khatami, M., Jalil, A. T., Naderifar, M., Safarpoor Dehkordi, F., & Shafiee, A. (2022). Biosynthesis of core–shell α-Fe2O3@Au nanotruffles and their biomedical applications. Biomass Conversion and Biorefinery, 1–15.
[4]                Zarini, M. K., & Amouzad Mahdiraji, E. (2024). Examining the secure communication network for the reliable use of micro-grids in the power system. Journal of Engineering in Industrial Research, 5(2), 101–115.
[5]                Torshizi, H. M., Nia, N. S., & Ariafar, M. R. (2026). Economic complexity versus GDP in shaping the environmental Kuznets Curve: A fuzzy-set analysis across resource curse vulnerability index levels. Resources Policy, 116, 105901.
[6]                Shahreza, M., Dehkordi, F., Kurbanova, S. K. A., & Sapayev, V. S. V. (2025). Occurrence of Staphylococcus aureus, Campylobacter jejuni, Listeria monocytogenes and Arcobacter butzleri in poultry meat. International Journal of Health and Medical Innovation (IJHMI), 2(1), 10–17.
[7]                Salehnia, N., Mokhtari Torshizi, H., & Seyedi, M. (2019). Impact of Health Costs and Good Governance Given Carbon Dioxide Threshold on Men's and Women's Health in Selected Developing Countries. Health Research Journal, 5(1), 32-40.
[8]                Safarpoor Dehkordi, F., Yahaghi, E., & Darian, E. K. (2014). Prevalence of antibiotic resistance in Escherichia coli isolated from poultry meat supply in Isfahan. Iranian Journal of Medical Microbiology, 8(2), 41–47.
[9]                Sadeghzadeh,A. (2026). Form, Proportion, and Harmony: Architectural Concepts in Facial Reconstruction. Medicinal, Psychological, and Health Research Journal (MPHRJ), 2(1), 49-60.
[10]             Sadeghzadeh,A. (2026). Designing the Human Face: Architectural Methodologies Applied to Maxillofacial Surgery. Medicinal, Psychological, and Health Research Journal (MPHRJ), 2(1), 35-48.
[11]             Rostami, F., Rahimi, E., Yahaghi, E., Khodaverdi Darian, E. K., et al. (2014). Isolation and evaluation of virulence factors of Salmonella typhimurium and Salmonella enteritidis in milk and dairy products. Iranian Journal of Medical Microbiology, 8(1), 54–61.
[12]             Rezaei-Tazangi, F, Forutan Mirhosseini, A., Fathi, A., Roghani-Shahraki, H. , Arefnezhad, R. and Vasei, F. (2024). Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis. Avicenna Journal of Phytomedicine, 14(4), 430-454.
[13]             Rezaei,M. and Eghdam Zamiri,R. (2026). Concurrent COVID‑19 Infection and Chemotherapy in Patients With Cancer and Its Impact on Thrombectomy‑Related Outcomes. Medicinal, Psychological, and Health Research Journal (MPHRJ), 2(1), 61-64.
[14]             Ranjbar, R., Dehkordi, F., & Heiat, M. (2020). The frequency of resistance genes in Salmonella enteritidis strains isolated from cattle. Iranian Journal of Public Health, 49(5), 968.
[15]             Pourhassan,A. and Pourhassan Mazarood,S. (2026). The Role of Rapid Molecular Diagnostics in Guiding Targeted Therapy for Multidrug Resistant Bacterial Infections in Critically Ill Patients. Medicinal, Psychological, and Health Research Journal (MPHRJ), 2(1), 65-71.
[16]             Nasiri, K., Amiri Moghaddam, M., Etajuri, E.A. et al., (2023), Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective. Clin Transl Oncol 25, 2801–2811.
[17]             Nasiri, K., Amiri Moghaddam, M., Etajuri, E.A. et al. (2023), Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective. Clin Transl Oncol 25, 2801–2811.
[18]             Mokhtari Torshizi, H., Salehnia, N., & Ahmadi Shadmehri, M. T. (2026). Are the different dimensions of globalisation necessary and sufficient for human development? A worldwide study. Journal of Human Development and Capabilities, 1–31.
[19]             Mohammad, W. T., Alijani, H., Faris, P., Salarkia, E., Naderifar, M., Akbarizadeh, M. R., Hashemi, N., Iravani, S., Jalil, A. T., Saleh, M. M., Fathi, A., & Khatami, M. (2023). Plant-mediated synthesis of sphalerite (ZnS) quantum dots, Th1-Th2 genes expression and their biomedical applications. South African Journal of Botany, 159, 249–259.
[20]             Mirzaei, K., Fathi, A., Asadinejad, S. M., & Moghadam, N. C. (2022). Study the antimicrobial effects of Zataria multiflora-based mouthwash on the microbial community of dental plaques isolated from children: A candidate of novel plant-based medicine. Academic Journal of Health Sciences, 37, 58–63.
[21]             Mahdiraji,E. A. and Zarini,M. K. (2025). Integration of Smart Materials in Loss of Excitation Protection Schemes for Synchronous Generators in Renewable Energy Systems. Journal of Chemical Engineering and Energy Materials, 1(2), 78-87.
[22]             Mahdiraji, E. A., & Zarini, M. K. (2025). Integration of smart materials in loss of excitation protection schemes for synchronous generators in renewable energy systems. Journal of Chemical Engineering and Energy Materials, 1(2), 78–87.
[23]             M.K. Zarini, E.A. Mahdiraji. (2024), Examining the Secure Communication Network for the Reliable Use of Micro-Grids in the Power System. J. Eng. Ind. Res., 5 (2):101-115.
[24]             Khodadadi Zarini, M., & Amouzad Mahdiraji, E. (2024). Review of energy management in micro grid in power engineering. Journal of Engineering in Industrial Research, 5(2), 90–99.
[26]             Badjadi, M. A., Zhu, H., Zhao, P., Zhang, F., Hou, D., Huang, L., & Micheal, M. (2025). Hybrid CNN-LSTM model for predicting wettability alterations in shale reservoir based on experimental techniques. Geoenergy Science and Engineering, 214217.
[27]             Badjadi, M. A., Zhu, H., Zhang, C., & Naseem, M. H. (2023). Enhancing water management in shale gas extraction through rectangular pulse hydraulic fracturing. Sustainability, 15(14), 10795.
[28]             Amouzad Mahdiraji, E., & Sedghi Amiri, M. (2020). Locating, sizing, and optimal planning of the distribution substations using vanadium flow battery storage to improve the efficiency of the power distribution network. International Journal of Smart Electrical Engineering, 9(1), 13–21.
[29]             Amouzad Mahdiraji, E., & Khodadadi Zarini, M. (2025). Advanced material-based cooling and insulation strategies for enhanced protection of synchronous generators under fault conditions. Journal of Chemical Engineering and Energy Materials, 1(3), 119–125.
[30]             Amouzad Mahdiraji, E., & Khodadadi Zarini, M. (2024). Smart frequency control in multi-carrier micro-grid with the presence of V2G electric vehicles. Journal of Artificial Intelligence in Electrical Engineering, 12(45), 53–69.
[31]             Amouzad Mahdiraji, E., & Amiri, M. S. (2021). Adaptive control of network frequency by doubly-fed induction generators using a data-driven method. Eurasian Journal of Science and Technology, 1(2).
[32]             Amouzad Mahdiraji, E. (2022). Multi-Objective Optimization of Distributed Generation Despite Energy Storage Systems for Optimal Management. International Journal of Engineering and Innovative Research, 4(1), 44-59.
[33]             Amouzad Mahdiraji, E. (2022). Microgrid control to ensure stability and increase flexibility in storage applications. Journal of Engineering in Industrial Research, 3(2), 69–76.
[34]             Amouzad Mahdiraji, E. (2020). Introducing a New Method to Increase Critical Clearing Time (CCT) and Improve Transient Stability of Synchronous Generator Using Brake Resistance. Gazi Journal of Engineering Sciences, 6(2), 138-144.
Zhou, L., Sun, T., & Liu, Q. (2022). The ethics of artificial intelligence in medical imaging: Current challenges and future perspectives. AI in Healthcare, 5(1), 44-57.