Medicinal, Psychological, and Health Research Journal (MPHRJ)

The Role of Saliva in Oral Health and Disease Diagnosis

Document Type : Original Article

Author

Frank Rebout

Department of Chemical Engineering, Calgary University, Canada

10.22034/mphrj.2026.585031.1084
Abstract
Saliva plays a fundamental role in maintaining oral homeostasis gained increasing attention as a valuable diagnostic fluid in modern medicine and dentistry. As a complex biological fluid secreted by major and minor salivary glands, saliva contains a wide range of components including enzymes, antimicrobial proteins, hormones, electrolytes, nucleic acids, and metabolites. These constituents contribute not only to the protection and lubrication of oral tissues but also to the regulation of microbial balance within the oral cavity. Recent advances in salivary diagnostics have highlighted the potential of saliva as a non invasive, cost effective, and easily accessible medium for detecting both oral and systemic diseases. The present study aims to explore the biological functions of saliva in oral health and evaluate its diagnostic potential in identifying oral diseases such as dental caries, periodontal disease, and oral cancer. In addition, the study examines the presence of biomarkers in saliva and their clinical relevance for early disease detection. A descriptive analytical research design employed, using previously published clinical studies and laboratory analyses of salivary components. The findings indicate that salivary biomarkers, including immunoglobulins, enzymes, inflammatory mediators, and microbial products, play a significant role in identifying pathological changes in the oral environment. Variations in salivary flow rate, pH, buffering capacity, and biochemical composition were associated with the development and progression of oral diseases. Furthermore, saliva-based diagnostic technologies demonstrated high potential for early detection of systemic conditions such as diabetes, viral infections, and certain cancers. Overall, saliva represents a promising diagnostic tool that can complement traditional diagnostic methods in dentistry and medicine. Its non invasive nature and ease of collection make it particularly suitable for large-scale screening and monitoring of disease progression. Future research should focus on improving the sensitivity and specificity of salivary biomarkers and integrating salivary diagnostics into routine clinical practice.

Graphical Abstract

The Role of Saliva in Oral Health and Disease Diagnosis

Keywords

Saliva
Oral Health
Salivary Biomarkers
Disease Diagnosis
Salivary Diagnostics
Subjects
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Medicinal, Psychological, and Health Research Journal (MPHRJ)
Volume 2, Issue 3
Spring 2026
Pages 168-176

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