Keywords = Calcium Hydroxylapatite
Number of Articles: 3
Outcomes of Temple Filler Injections in Facial Rejuvenation: A Systematic Review and Meta-analysis

Outcomes of Temple Filler Injections in Facial Rejuvenation: A Systematic Review and Meta-analysis

Volume 2, Issue 2, Winter 2026, Pages 96-105

https://doi.org/10.22034/mphrj.2026.574535.1065

Aida Sadeghzadeh

Abstract Temple volumization has become an integral component of facial rejuvenation, aiming to restore youthful contours and address age-related soft tissue loss. Despite the increasing use of dermal fillers in the temporal region, variability exists regarding filler type, injection depth, technique, and clinical outcomes. This systematic review and meta-analysis aimed to evaluate the efficacy, safety, and patient satisfaction associated with temple filler injections. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Cochrane Library databases from January 2000 to December 2025. Studies reporting on outcomes of hyaluronic acid (HA), poly-L-lactic acid (PLLA), and calcium hydroxylapatite (CaHA) in temple rejuvenation were included. Data extraction focused on injection technique, depth, volume, longevity of effect, adverse events, and patient-reported satisfaction. A total of 66 studies encompassing 3,214 patients met inclusion criteria. Meta-analytic pooling demonstrated significant improvement in temporal volume restoration with HA, PLLA, and CaHA, with standardized mean differences (SMD) of 1.12 (95% CI: 0.85–1.39), 1.05 (95% CI: 0.77–1.32), and 0.98 (95% CI: 0.70–1.26), respectively. Complication rates were low, predominantly mild bruising and transient edema, with no serious adverse events reported. Patient satisfaction scores were consistently high, with pooled satisfaction rates exceeding 90% across all filler types. Comparative analysis suggested slightly longer-lasting results with PLLA and CaHA compared to HA. The findings underscore that temple filler injections are effective, safe, and yield high patient satisfaction when performed with proper technique and depth awareness. Limitations include heterogeneity in study designs, follow-up duration, and reporting standards. Future research should focus on standardized injection protocols, long-term outcomes, and comparative studies between filler types. Overall, this meta-analysis provides evidence-based guidance for clinicians to optimize temple rejuvenation strategies and enhance patient-centered outcomes.

An approach to structural facial rejuvenation with fillers in women

An approach to structural facial rejuvenation with fillers in women

Volume 1, Issue 6, June 2025, Pages 178-186

https://doi.org/10.22034/mphrj.2025.531134.1019

Maryam Milanifard, Amir Hashemloo

Abstract Structural facial rejuvenation with dermal fillers has become a cornerstone in non-surgical aesthetic treatments, particularly for women seeking natural, youthful, and harmonious facial contours. This approach focuses on restoring volume loss and supporting the underlying facial architecture rather than simply filling superficial wrinkles. By targeting key structural areas such as the midface, cheeks, jawline, and temples, practitioners can effectively counteract the effects of aging, including soft tissue descent, bone resorption, and fat compartment atrophy. The use of hyaluronic acid-based fillers and calcium hydroxylapatite has demonstrated safety, biocompatibility, and long-lasting outcomes in volumizing and lifting facial tissues. This method emphasizes a comprehensive understanding of facial anatomy, aging dynamics, and individualized treatment planning to achieve balanced and natural-looking results. Moreover, recent advances in imaging technologies and injection techniques have enhanced precision and minimized risks such as vascular complications and irregularities. Clinical studies support the efficacy of structural rejuvenation, reporting high patient satisfaction and improved facial aesthetics. However, successful outcomes require skilled assessment, tailored protocols, and an integrative approach combining filler use with other modalities when necessary. This article reviews current concepts, materials, and procedural strategies for structural facial rejuvenation in women, highlighting the importance of a holistic and anatomically informed technique to restore youthful facial contours safely and effectively.

Contouring Plus: A Comprehensive Approach of the Lower Third of the Face with Calcium Hydroxylapatite and Hyaluronic Acid

Contouring Plus: A Comprehensive Approach of the Lower Third of the Face with Calcium Hydroxylapatite and Hyaluronic Acid

Volume 1, Issue 5, May 2025, Pages 143-150

https://doi.org/10.22034/mphrj.2025.530934.1014

Amir Hashemloo, Maryam Milanifard

Abstract The aesthetic rejuvenation of the lower third of the face, particularly the jawline, has become a pivotal focus in modern cosmetic dermatology. This study introduces “Contouring Plus,” a novel, minimally invasive approach that combines the biostimulatory properties of Calcium Hydroxylapatite (CaHA) with the versatile volumizing and contouring capabilities of Hyaluronic Acid (HA) fillers. The protocol involves a strategic layering technique where CaHA is injected supraperiosteally along the mandibular border to provide structural support and stimulate neocollagenesis, while HA fillers are administered in the subcutaneous plane to refine contours and enhance soft tissue projection. The article presents a case series involving four patients aged 29 to 54, treated in a single session and evaluated over a 90-day period using clinical photography and three-dimensional imaging. Results demonstrated significant improvement in jawline definition and patient satisfaction, with minimal adverse events such as mild bruising and swelling. The safety profile is supported by adherence to precise anatomical landmarks and injection planes, minimizing risks of vascular complications. The combined filler technique capitalizes on the long-term collagen-stimulating effects of CaHA alongside the immediate, moldable benefits of HA, resulting in durable and natural-looking facial rejuvenation. This hybrid approach provides clinicians with an evidence-based, adaptable protocol for addressing age-related volume loss and contour irregularities in the lower face. Future studies are warranted to assess long-term outcomes and optimize filler combinations.